Publications

2010

Wouters MA, Fan SW, Haworth NL Disulfides as redox switches: from molecular mechanisms to functional significances. Antioxid Redox Signal. 2010 Jan;12(1):53-91 Open Access

Sparrow DB, Sillence D, Wouters MA, Turnpenny PD, Dunwoodie SL. Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis. Eur J Hum Genet. 2010 Jun;18(6):674-9 Open Access

Haworth NL, Liu JY, Fan SW, Gready JE, Wouters MA Estimating Relative Disulfide Energies: An Accurate Ab Initio Potential Energy Surface. Aust J Chem. 2010;63(3):379-387

2009

Teber ET, Liu JY, Ballouz S, Fatkin D and Wouters MA Comparison of automated candidate gene prediction systems using genes implicated in type 2 diabetes by genome-wide association studies. BMC Bioinformatics. 2009 Jan 30;10 Suppl 1:S69 PubMed Open Access

Kurz M, Iturbe-Ormaeitxe I, Jarrott R, Shouldice SR, Wouters MA, Frei P, Glockshuber R, Oneill S, Heras B, Martin J STRUCTURAL AND FUNCTIONAL CHARACTERISATION OF THE OXIDOREDUCTASE alpha-DSBA1 FROM WOLBACHIA PIPIENTIS. Antioxid Redox Signal. 2009 Mar 5 Open Access

Fan SW, George RA, Haworth NL, Feng LL, Liu JY, Wouters MA Conformational changes in redox pairs of protein structures. Protein Sci 2009 Aug;18(8):1745-65 Open Access

2008

George RA, Smith TD, Callaghan S, Hardman L, Pierides C, Horaitis O, Wouters MA, Cotton RG Response to Stenson et al on the review of general mutation databases. J Med Genet. 2008 May;45(5):319-20. ;Open Access

George RA, Smith TD, Callaghan S, Hardman L, Pierides C, Horaitis O, Wouters MA, Cotton RG General mutation databases: analysis and review. J Med Genet. 2008 Feb;45(2):65-70. Epub 2007 Sep 24. Review. Open Access

Pang CN, Lin K, Wouters MA, Heringa J, George RA Identifying foldable regions in protein sequence from the hydrophobic signal. Nucleic Acids Res. 2008 Feb;36(2):578-88. Epub 2007 Dec 1. PubMed Open Access

2007

Wouters MA, George RA, Haworth NL "Forbidden" disulfides: their role as redox switches Curr Protein Pept Sci. 2007 Oct;8(5):484-95. Review. Open Access

Haworth NL, Gready JE, George RA, Wouters MA Evaluating the stability of disulfide bridges in proteins: a torsional potential energy surface for diethyl disulfide. Molecular Simulation. 2007 Vol 33:475-485 Open Access

2006

George RA, Liu JY, Feng LL, Bryson-Richardson RJ, Fatkin D and Wouters MA Analysis of protein sequence and interaction data for candidate disease gene prediction. Nucleic Acids Res. 2006;(34):e130. Epub 2006 Oct 4 Pubmed Open Access

Haworth NL, Feng LL, Wouters MA. High torsional energy disulfides: relationship between cross-strand disulfides and right-handed. J Bioinform Comput Biol. 2006; 4:155-68. Open Access

Sparrow DB, Chapman G, Wouters MA, Whittock NV, Ellard S, Fatkin D, Turnpenny PD, Kusumi K, Sillence D, Dunwoodie SL. Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. Am J Hum Genet. 2006; 78: 28-37 PubMed

Begg GE, Carrington L, Stokes PH, Matthews JM, Wouters MA, Husain A, Lorand L, Iismaa SE, Graham RM Mechanism of allosteric regulation of transglutaminase 2 by GTP. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19683-8. Epub 2006 Dec 18. PubMed Open Access

2005

Chu CK, Feng LL, Wouters MA. Comparison of sequence and structure-based datasets for nonredundant structural data mining. Proteins. 2005; 60:577-83 PubMed

Wouters MA, Rigoutsos I, Chu CK, Feng LL, Sparrow DB, Dunwoodie SL. Evolution of distinct EGF domains with specific functions. Protein Sci 2005; 14:1091 PubMed

2004

Whittock NV, Sparrow DB, Wouters MA, Sillence D, Ellard S, Dunwoodie SL, Turnpenny PD. Mutated MESP2 causes spondylocostal dysostosis in humans. Am J Hum Genet 2004; 74:1249-54 PubMed

Wouters MA, Lau KK, Hogg PJ. Cross-strand disulphides in cell entry proteins: poised to act. Bioessays 2004; 26:73-9 Open Access

2003

Iismaa SE, Holman S, Wouters MA, Lorand L, Graham RM, Husain A. Evolutionary specialization of a tryptophan indole group for transition state stabilization by eukaryotic transglutaminases. Proc Natl Acad Sci USA 2003; 100:12636-41 http://www.pnas.org/. PubMed Open Access

Wouters MA, Liu K, Riek P, Husain A. A despecialization step underlying evolution of a family of serine proteases. Mol Cell 2003; 12:343-54 PubMed http://www.molecule.org/.

How enzymes and other proteins have evolved is critical to understanding how they function and how they may be altered to advantage, to produce "designer" enzymes with new functions. In this paper, a Jurassic enzyme (over 170 million years old) is recreated and studied, revealing a major new understanding of how it evolved and functions.

2001

Fernandez M, Liu X, Wouters MA, Heyberger S, Husain A Angiotensin I-converting enzyme transition state stabilization by HIS1089: evidence for a catalytic mechanism distinct from other gluzincin metalloproteinases. J Biol Chem 2001; 276: 4998-5004 Open Access

Liu X, Fernandez M, Wouters MA, Heyberger S, Husain A Arg(1098) is critical for the chloride dependence of human angiotensin I-converting enzyme C-domain catalytic activity. J Biol Chem 2001; 276: 33518-25 Open Access

Wouters MA, Husain A Changes in zinc ligation promote remodeling of the active site in the zinc hydrolase superfamily. Mol Biol 2001; 314: 1191-207 PubMed

1995

Wouters MA, Curmi PM An analysis of side chain interactions and pair correlations within antiparallel beta-sheets: the differences between backbone hydrogen-bonded and non-hydrogen-bonded residue pairs. Proteins 1995; 22:119-31 PubMed